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Sanofi Pasteur: The vaccines division of Sanofi-Aventis group
Fluzone® Intradermal Influenza Virus Vaccine

Tiny needle. Big protection.

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Intradermal or Fluzone High-Dose vaccine

Image: Fluzone® Intradermal Influenza Virus Vaccine, tiny needle. big protection.
Image: Intradermal vaccine needles are injected into the skin rather than deep into the muscle.

Typical vaccine needles go through the skin, then a layer of fat, and finally enter the muscle.1 Intradermal vaccines are injected into the skin through a small, ultra-thin needle.2,3 Because the skin has more immune cells than the muscle, an intradermal vaccine is able to use the skin's natural defenses, providing a similar level of protection as the traditional flu shot.2,4

See for yourself how the needle measures up.

The Fluzone Intradermal vaccine needle is comparable in size to a penny.

Have questions? Get answers.

How is Fluzone Intradermal vaccine different from the flu shot I received last year?

The microneedle only goes as deep as the skin.2,3 It contains less vaccine than the traditional flu shot (0.1 mL compared to 0.5 mL) and is designed to help protect you against the flu.2,5

Where is the microneedle injected?

Fluzone Intradermal vaccine is given in your upper arm — the same spot you were given your flu shot from last year.2,5

How small is the microneedle?

Fluzone Intradermal vaccine is the first FDAa-approved intradermal flu vaccine in the United States.6 The ultra-thin tip is only 1.5 mm long; that's the same thickness of a US penny!3,7

a FDA = Food and Drug Administration.

What reaction, if any, can I expect from Fluzone Intradermal vaccine?

The most common side effects are redness, swelling, or a raised bump where the vaccine was injected.2 This is because the vaccination is given just under the skin.8 Other side effects include pain and itching.2 These reactions typically are not serious and generally resolve on their own within a few days.6

Is Fluzone Intradermal vaccine for everyone?

Fluzone Intradermal vaccine is approved only for adults 18-64 years of age.2 However, other flu vaccines are available for patients 6 months of age and older.5

How much does Fluzone Intradermal vaccine cost?

Flu vaccines are typically covered by most insurance companies.9 In addition, coverage for children, adolescents, and others are mandated under the provisions of the Affordable Care Act.10 For more information on your specific influenza vaccine coverage, please contact your insurance company.

Where can I get Fluzone Intradermal vaccine?

To find the vaccine in a location closest to you, use the Fluzone Locator.

There’s a Fluzone vaccine for you.

Learn About Other Fluzone Vaccines.

There’s a Fluzone vaccine for you.

Important Safety Information


Fluzone, Fluzone Intradermal, and Fluzone High-Dose vaccines are given to help prevent influenza disease caused by influenza A and B strains contained in each vaccine.

Fluzone vaccine is intended for persons 6 months of age and older. Fluzone Intradermal vaccine is intended for persons 18 through 64 years of age. Fluzone High-Dose vaccine is intended for persons 65 years of age and older.

Approval of Fluzone High-Dose vaccine is based on superior immune response relative to Fluzone vaccine. Data demonstrating a decrease in influenza disease after vaccination with Fluzone High-Dose vaccine relative to Fluzone vaccine are not available.

Safety Information

Side effects to Fluzone and Fluzone High-Dose vaccines include pain, redness, and swelling at the injection site; muscle aches, fatigue, headache, and fever (irritability, abnormal crying, drowsiness, appetite loss, and vomiting in young children receiving Fluzone vaccine). Redness, firmness, swelling, and itching at the injection site occur more frequently with Fluzone Intradermal vaccine than with Fluzone vaccine. Other side effects to Fluzone Intradermal vaccine include pain at the injection site. Other side effects may occur. Fluzone, Fluzone Intradermal, and Fluzone High-Dose vaccines should not be administered to anyone with a severe allergic reaction (eg, anaphylaxis) to any vaccine component, including eggs, egg products, or thimerosal (the multidose vial is the only presentation containing thimerosal), or to a previous dose of any influenza vaccine.

Tell the doctor if you/your child has ever experienced Guillain-Barré syndrome (severe muscle weakness) after a previous dose of influenza vaccine. If you notice any other problems or symptoms following vaccination, please contact your health care professional immediately. Vaccination with Fluzone, Fluzone Intradermal, or Fluzone High-Dose vaccine may not protect all individuals.

For more information about Fluzone, Fluzone Intradermal, and Fluzone High-Dose vaccines, talk to your health care professional and see complete Patient Information.


  1. Atkinson W, Wolfe S, Hamborsky J, McIntyre L, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book). 12th ed. Washington, DC: Public Health Foundation; 2011.
  2. Fluzone Intradermal vaccine [Prescribing Information]. Swiftwater, PA: Sanofi Pasteur Inc.; 2014.
  3. Lambert PH, Laurent PE. Intradermal vaccine delivery: will new delivery systems transform vaccine administration? Vaccine. 2008;26(26):3197-3208.
  4. Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med. 2004;351(22):2295-2301.
  5. Fluzone vaccine [Prescribing Information]. Swiftwater, PA: Sanofi Pasteur Inc.; 2014.
  6. Icardi G, Orsi A, Ceravolo A, Ansaldi F. Current evidence on intradermal influenza vaccines administered by SoluviaTM licensed micro injection system. Hum Vaccin Immunother. 2012;8(1):67-75.
  7. US Mint. Coin specifications. Accessed September 19, 2014.
  8. Reygrobellet C, Viala-Danten M, Meunier J, Weber F, Nguyen VH. Perception and acceptance of intradermal influenza vaccination. Hum Vaccine. 2010;6(4):336-345.
  9. US Department of Health and Human Services (DHHS). 2010 National Vaccine Plan: Protecting the Nation’s Health through Immunization. Washington, DC: US Department of Health and Human Services; 2010.
  10. Rosenbaum S. The Patient Protection and Affordable Care Act: implications for public health policy and practice. Public Health Rep. 2011;126(1):130-135.


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