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Image: Fluzone® Intradermal Influenza Virus Vaccine

Tiny needle. Big protection.

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Ask your health care provider about Fluzone
Intradermal Quadrivalent vaccine or Fluzone High-Dose vaccine.

Image: Fluzone® Intradermal Influenza Virus Vaccine, tiny needle. big protection.
Image: Intradermal vaccine needles are injected into the skin rather than deep into the muscle.

Typical vaccine needles go through the skin, then a layer of fat, and finally enter the muscle.1 Intradermal vaccines are injected into the skin through a small, ultra-thin needle.1,2 Because the skin has more immune cells than the muscle, the intradermal vaccine is able to use the skin's natural defenses, providing a similar level of protection as the traditional flu shot.3,4

Fluzone Intradermal Quadrivalent vaccine is designed to help protect people 18 through 64 years of age against 4 different strains of the flu: 2 influenza A viruses and 2 influenza B viruses.4 Current trivalent flu vaccines help protect against 2 influenza A viruses but only 1 influenza B virus.5 You get 4-strain flu protection through a much smaller needle with Fluzone Intradermal Quadrivalent vaccine.1,4

See for yourself how the needle measures up.


The Fluzone Intradermal vaccine needle is comparable in size to a penny.

Have questions? Get answers.

What does quadrivalent mean?

Quad means "four" of something. The quadrivalent vaccine helps protects against 4 different strains of the flu: 2 influenza A viruses and 2 influenza B viruses. 4 (Traditional Influenza vaccines only help protect against 3 strains.)5 Helping to protect against 2 influenza B viruses is important. Data show that influenza B viruses are responsible for a substantial amount of flu-related hospitalizations and complications. 6,7

How is Fluzone Intradermal Quadrivalent vaccine different from the flu shot I received in the past?

The microneedle's ultra-thin tip is only 1.5 mm long; that's the thickness of a U.S. penny! 2,8
The microneedle only goes as deep as the skin. And it helps protect you against 4 strains of the flu. 4

Is Fluzone Intradermal Quadrivalent vaccine for everyone?

Fluzone Intradermal Quadrivalent vaccine is approved only for adults 18-64 years of age.4 However, other flu vaccines are available for persons 6 months of age and older.9,10

Is Fluzone Intradermal Quadrivalent vaccine covered by insurance?

Preventive care like Fluzone Intradermal Quadrivalent vaccine may be covered with no co-payment or deductible under private insurance policies. 11,12

Where can I get Fluzone Intradermal Quadrivalent vaccine?

To find the vaccine at a location closest to you, use the Fluzone Locator.

There’s a Fluzone vaccine for you.

Learn About Other Fluzone Vaccines.


There’s a Fluzone vaccine for you.

Important Safety Information

Indication

Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, and Fluzone High-Dose vaccines are given to help prevent influenza disease caused by influenza A and B strains contained in each vaccine.

Fluzone Quadrivalent vaccine is given to people 6 months of age and older. Fluzone Intradermal Quadrivalent vaccine is given to people 18 through 64 years of age. Fluzone High-Dose vaccine is given to people 65 years of age and older.

Safety Information

Side effects to Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, and Fluzone High-Dose vaccines include pain and swelling at the injection site (also itching in adults receiving Fluzone Intradermal Quadrivalent vaccine); muscle aches, fatigue, headache, and fever (also irritability, abnormal crying, drowsiness, appetite loss, and vomiting in young children receiving Fluzone Quadrivalent vaccine). Itching, redness, swelling, and firmness at the injection site occurred more frequently with Fluzone Intradermal vaccine (containing 3 influenza strains) than with Fluzone vaccine. Other side effects may occur.

Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, and Fluzone High-Dose, vaccines should not be administered to anyone with a severe allergic reaction (eg, anaphylaxis) to any vaccine component, including eggs, egg products, or thimerosal (the multidose vial is the only presentation containing thimerosal), or to a previous dose of any influenza vaccine.

Tell the doctor if you/your child has ever experienced Guillain-Barré syndrome (severe muscle weakness) after a previous dose of influenza vaccine. If you notice any other problems or symptoms following vaccination, please contact your health care professional immediately. Vaccination with Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, or Fluzone High-Dose vaccine may not protect all individuals.

For more information about Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, or Fluzone High-Dose vaccine, talk to your health care professional and see complete Patient Information.

References

  1. Hamborsky J, Kroger A, Wolfe C. Vaccine Administration. In: Hamborsky J, Kroger A, Wolfe C, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book). 13th ed. Washington, DC: Public Health Foundation; 2015:79–106.
  2. Lambert PH, Laurent PE. Intradermal vaccine delivery: will new delivery systems transform vaccine administration? Vaccine. 2008;26(26):3197–3208.
  3. Reygrobellet C, Viala-Danten M, Meunier J, Weber F, Nguyen VH. Perception and acceptance of intradermal influenza vaccination. Hum Vaccin. 2010;6(4):336–345.
  4. Fluzone Intradermal Quadrivalent vaccine [Prescribing Information]. Swiftwater, PA: Sanofi Pasteur Inc.; 2015.
  5. Hamborsky J, Kroger A, Wolfe C. Influenza. In: Hamborsky J, Kroger A, Wolfe C, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book). 13th ed. Washington, DC: Public Health Foundation; 2015:187–208.
  6. Belshe RB. The need for quadrivalent vaccine against seasonal influenza. Vaccine. 2010;28(suppl 4):D45–D53.
  7. Ambrose CS, Levin MJ. The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother. 2012;8(1):81–88.
  8. US Mint. Coin specifications. http://www.usmint.gov/about_the_mint/?action=coin_specifications. Accessed June 5, 2015.
  9. Centers for Disease Control and Prevention (CDC). Recommended immunization schedules for persons aged 0 through 18 years — United States, 2015. http://www.cdc.gov/vaccines/schedules/downloads/child/0-18yrs-child-combined-schedule.pdf. Accessed June 10, 2015.
  10. CDC. Recommended adult immunization schedule: United States - 2015. http://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule.pdf. Accessed June 10, 2015. Fluzone vaccine [Prescribing Information]. Swiftwater, PA: Sanofi Pasteur Inc.; 2015.
  11. US Department of Health and Human Services (DHHS). 2010 National Vaccine Plan: Protecting the Nation’s Health through Immunization Washington, DC: US Department of Health and Human Services; 2010.
  12. Rosenbaum S. The Patient Protection and Affordable Care Act: implications for public health policy and practice. Public Health Rep. 2011;126(1):130–135.

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